The role of a conserved threonine residue in the leader peptide of lasso peptide precursors.
نویسندگان
چکیده
The conserved threonine (Thr) residue in the penultimate position of the leader peptide of lasso peptides microcin J25 and capistruin can be effectively replaced by several amino acids close in size and shape to Thr. These findings suggest a model for lasso peptide biosynthesis in which the Thr sidechain is a recognition element for the lasso peptide maturation machinery.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 13 شماره
صفحات -
تاریخ انتشار 2012